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Effect of quinidine on the intestinal secretion of digoxin in guinea pigs
Author(s) -
Schäfer S. G.,
Fichtl B.,
Doering W.
Publication year - 1984
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510050209
Subject(s) - digoxin , quinidine , medicine , endocrinology , secretion , chemistry , guinea pig , cardiac glycoside , pharmacology , ouabain , heart failure , sodium , organic chemistry
Following i.v. injection of digoxin (10 μg kg −1 ) the ratio between digoxin concentrations in the lumen of jejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8·7, indicating net secretion of digoxin against a concentration gradient. In quinidine treated animals (100 mg kg −1 p.o., 2h before experiment) both the L/P ratio (5·7; p < 0·01) and the digoxin content of jejunal tissue (– 32 per cent; p < 0·01) were markedly reduced. It is suggested that quinidine reduces the extrarenal clearance of digoxin at least in part by inhibiting the intestinal secretion of this glycoside.