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Effect of using an incorrect elimination rate constant in application of the Wagner–Nelson method to theophylline data in cases of zero order absorption
Author(s) -
Wagner John G.
Publication year - 1984
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510050110
Subject(s) - theophylline , elimination rate constant , zero order , zero (linguistics) , constant (computer programming) , reaction rate constant , order (exchange) , mathematics , absorption (acoustics) , chemistry , thermodynamics , first order , pharmacokinetics , pharmacology , medicine , physics , kinetics , computer science , optics , philosophy , economics , classical mechanics , volume of distribution , programming language , linguistics , finance
Some authors have used an elimination rate constant derived from one theophylline treatment (e.g. the elixir) to apply the Wagner–Nelson method to concentration–time data from another treatment (e.g. a sustained‐release form). Since there is considerable intrasubject variation in the elimination rate constant of theophylline such a practice usually involves use of an incorrect rate constant. By means of theoretical treatment and simulations the effects of such a practice are shown and illustrated.