Thiazides XI: Partitioning of chlorothiazide in red blood cells after oral administration | Zendy

Shah Vinod P. | Zendy; Walker Mark A. | Zendy; Hunt John P. | Zendy; Schuirmann Donald | Zendy; Prasad Vadlamani K. | Zendy; Cabana Bernard E. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Thiazides XI: Partitioning of chlorothiazide in red blood cells after oral administration

Author(s) -

Shah Vinod P.,

Walker Mark A.,

Hunt John P.,

Schuirmann Donald,

Prasad Vadlamani K.,

Cabana Bernard E.

Publication year - 1984

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510050108

Subject(s) - chlorothiazide , oral administration , pharmacology , pharmacokinetics , chemistry , medicine , drug , endocrinology , diuretic

Uptake of chlorothiazide by red blood cells after oral drug administration was investigated. Chlorothiazide was administered to normal healthy volunteers as a solution or a tablet. Frequent blood samples were collected and analysed by a specific HPLC method. The results indicate that there is a significant uptake of chlorothiazide by red blood cells, resulting in a higher blood AUC compared to plasma AUC.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research