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Thiazides XI: Partitioning of chlorothiazide in red blood cells after oral administration
Author(s) -
Shah Vinod P.,
Walker Mark A.,
Hunt John P.,
Schuirmann Donald,
Prasad Vadlamani K.,
Cabana Bernard E.
Publication year - 1984
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510050108
Subject(s) - chlorothiazide , oral administration , pharmacology , pharmacokinetics , chemistry , medicine , drug , endocrinology , diuretic
Uptake of chlorothiazide by red blood cells after oral drug administration was investigated. Chlorothiazide was administered to normal healthy volunteers as a solution or a tablet. Frequent blood samples were collected and analysed by a specific HPLC method. The results indicate that there is a significant uptake of chlorothiazide by red blood cells, resulting in a higher blood AUC compared to plasma AUC.