Premium
A second peak in uptake of gentamicin by rat kidney after cessation of treatment
Author(s) -
Chareul C.,
Faccini J.,
Monro A.,
Nachbaur J.
Publication year - 1984
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510050104
Subject(s) - gentamicin , kidney , medicine , aminoglycoside , pharmacology , endocrinology , physiology , chemistry , antibiotics , biochemistry
Gentamicin was administered s.c. to rats once daily for 7 days at 5 mg kg −1 . At the end of this period renal concentrations of gentamicin declined from day 1 to day 5 post‐dosing, but showed a second peak on day 8, after which they declined again through days 16 and 22. This second peak coincided with a peak of mitotic activity in the kidney, suggesting that this organ, while recovering from gentamicin‐induced damage, passes through a temporary phase during which it has increased affinity for gentamicin.