A second peak in uptake of gentamicin by rat kidney after cessation of treatment | Zendy

Chareul C. | Zendy; Faccini J. | Zendy; Monro A. | Zendy; Nachbaur J. | Zendy

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A second peak in uptake of gentamicin by rat kidney after cessation of treatment

Author(s) -

Chareul C.,

Faccini J.,

Monro A.,

Nachbaur J.

Publication year - 1984

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510050104

Subject(s) - gentamicin , kidney , medicine , aminoglycoside , pharmacology , endocrinology , physiology , chemistry , antibiotics , biochemistry

Gentamicin was administered s.c. to rats once daily for 7 days at 5 mg kg −1 . At the end of this period renal concentrations of gentamicin declined from day 1 to day 5 post‐dosing, but showed a second peak on day 8, after which they declined again through days 16 and 22. This second peak coincided with a peak of mitotic activity in the kidney, suggesting that this organ, while recovering from gentamicin‐induced damage, passes through a temporary phase during which it has increased affinity for gentamicin.

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