Premium
Comparative pharmacokinetic analysis of a novel sustained release dosage form of valproic acid in dogs
Author(s) -
Bialer Meir,
Friedman Michael,
Dubrovsky Joseph
Publication year - 1984
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510050102
Subject(s) - bioavailability , valproic acid , pharmacokinetics , dosage form , pharmacology , ingestion , chemistry , drug , absorption (acoustics) , plasma concentration , oral administration , chromatography , medicine , epilepsy , biochemistry , physics , psychiatry , acoustics
A new sustained release dosage form of valproic acid (VPA) was developed. The new sustained release dosage form was administered (twice, with and without food) to five dogs in comparison to a standard tablet (Depakine, Labaz) and an i.v. preparation of the drug. Drug level monitoring in the plasma was performed by a GLC assay. Results indicate that the sustained release formulation exhibited a more prolonged and uniform absorption rate, yielded more sustained plasma levels after ingestion, and showed an overall bioavailability of 0·84 (95 per cent C.I. = 0·72, 0·96) relative to an equivalent dose of a conventional tablet.