Comparative pharmacokinetic analysis of a novel sustained release dosage form of valproic acid in dogs | Zendy

Bialer Meir | Zendy; Friedman Michael | Zendy; Dubrovsky Joseph | Zendy

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Comparative pharmacokinetic analysis of a novel sustained release dosage form of valproic acid in dogs

Author(s) -

Bialer Meir,

Friedman Michael,

Dubrovsky Joseph

Publication year - 1984

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510050102

Subject(s) - bioavailability , valproic acid , pharmacokinetics , dosage form , pharmacology , ingestion , chemistry , drug , absorption (acoustics) , plasma concentration , oral administration , chromatography , medicine , epilepsy , biochemistry , physics , psychiatry , acoustics

A new sustained release dosage form of valproic acid (VPA) was developed. The new sustained release dosage form was administered (twice, with and without food) to five dogs in comparison to a standard tablet (Depakine, Labaz) and an i.v. preparation of the drug. Drug level monitoring in the plasma was performed by a GLC assay. Results indicate that the sustained release formulation exhibited a more prolonged and uniform absorption rate, yielded more sustained plasma levels after ingestion, and showed an overall bioavailability of 0·84 (95 per cent C.I. = 0·72, 0·96) relative to an equivalent dose of a conventional tablet.

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