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Pharmacokinetics of mepindolol administered alone and in combination with hydrochlorothiazide—a bioequivalence study
Author(s) -
Krause W.,
Lennert Chr.
Publication year - 1983
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510040406
Subject(s) - hydrochlorothiazide , bioequivalence , bioavailability , pharmacokinetics , pharmacology , medicine , chemistry , blood pressure
The bioavailability and pharmacokinetics of 10 mg of mepindolol sulphate and of 25 mg of hydrochlorothiazide were compared in a cross‐over design in five healthy volunteers after the administration of either the single drugs (Corindolan® and Esidrix®) or in combination (Tenesor®). Maximum concentrations of mepindolol in the plasma of 25 ng ml −1 were achieved 1·6 h after both treatments and the half‐life of disposition was calculated to be 4·5 h, being somewhat longer after the combination tablet. The amount of hydrochlorothiazide renally eliminated up to 48 h after drug intake was about 60 per cent of the dose. The half‐life of renal excretion was 3 h. The two formulations of mepindolol sulphate and hydrochlorothiazide proved to be bioequivalent with a tendency to better mepindolol bioavailability in the combination form.