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Steady‐state distribution volume in physiologic multi‐organ systems
Author(s) -
Weiss Michael
Publication year - 1983
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510040207
Subject(s) - volume of distribution , steady state (chemistry) , distribution (mathematics) , distribution volume , volume (thermodynamics) , pharmacokinetics , blood volume , circulatory system , chemistry , biological system , mathematics , pharmacology , thermodynamics , medicine , biology , anesthesia , cardiology , physics , mathematical analysis
A unique definition of the apparent volume of distribution at steady‐state is presented which is consistent with the realistic concept of blood concentration differences within the circulatory system. A physiologically based pharmacokinetic model consisting of eliminating and non‐eliminating organs is used to predict the effect of drug elimination upon the steady‐state distribution volume.