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Personality traits and theophylline metabolism
Author(s) -
Hartzema Abraham G.,
Pancorbo Sal,
Davis Scott
Publication year - 1982
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510030404
Subject(s) - theophylline , neuroticism , personality , extraversion and introversion , medicine , population , big five personality traits , eysenck personality questionnaire , heart failure , psychiatry , psychology , social psychology , environmental health
The objectives of this study were to investigate the relationship between personality trait variables and theophylline disposition in asthmatic patients. Twenty‐five patients admitted to a hospital who required intravenous theophylline for bronchodilation were studied. Data on theophylline half‐life, and the patients' histories on congestive heart failure, liver disease, and smoking behaviour were abstracted. Eysenck's personality inventory was administered to obtain a score on the two personality traits: neuroticism and extroversy. High neurotic patients showed a significantly ( p < 0.005) lower theophylline half‐life. Neuroticism appeared to be, in this patient population, a more important determinant of theophylline half‐life than variables such as congestive heart failure, liver disease, or smoking behaviour.