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Pharmacokinetics of 14 C‐DMPS (sodium‐1,3 14 C‐2,3‐dimercaptopropane‐l‐sulphonate) in beagle dogs
Author(s) -
Wiedemann P.,
Fichtl B.,
Szinicz L.
Publication year - 1982
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510030309
Subject(s) - pharmacokinetics , beagle , chemistry , oral administration , bolus (digestion) , sodium , pharmacology , medicine , organic chemistry
The pharmacokinetics of labelled DMPS (sodium‐1,3 14 C‐2,3‐dimercaptopropane‐1‐sulphonate) have been studied in four beagle dogs following bolus intravenous injection (65‐7 μmolkg −1 ) and oral administration (197μmol kg −1 ). Following intravenous injection the main kinetic parameters were t 1/2 = 43min, V β = 160 ml kg −1 , and plasma clearance Cl p = 2.6ml min −1 kg −1 . Following oral administration 14 C‐DMPS is rapidly absorbed with peak concentrations (478 ± 25 umol 1 −1 ) measured after 30–45 min. About 60 per cent of the oral dose was absorbed. Estimates of t 1/2 , V β , and Cl p after oral administration were in close agreement with the values obtained in the intravenous study. 14 C‐DMPS is eliminated from the body by the kidneys. About 70 per cent of 14 C‐DMPS in dog plasma are bound to proteins. Binding is even higher in plasma from rat and man.