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Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N ‐dealkylated products
Author(s) -
Achari R.,
Beckett A. H.
Publication year - 1982
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510030303
Subject(s) - excretion , chemistry , buccal administration , absorption (acoustics) , partition coefficient , chromatography , pharmacology , biochemistry , medicine , materials science , composite material
Abstract Buccal uptake, partition characteristics, ionization constants, and urinary excretion were studied for zipeprol and two of its metabolities. Buccal uptake, measured in a single subject, was found to be correlated with n ‐heptane/water (ph 7.4) partition values of the compounds, and with proportional excreation of the unchanged drug. The importance of the shape of buccal uptake‐pH curves in the prediction of absorption and excretion of these compounds is discussed.