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Bioavailability of phenylbutazone from a new enteric‐coated formulation with superior dissolution characteristics
Author(s) -
John V. A.,
Goldsborough S.,
Morrison P. J.,
Rogers H. J.,
Spector R. G.,
Bradbrook I. D.
Publication year - 1982
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510030109
Subject(s) - bioavailability , phenylbutazone , pharmacology , drug , pharmacokinetics , absorption (acoustics) , chemistry , systemic circulation , chromatography , enteric coated , absorption rate , dissolution , dosing , dosage form , medicine , materials science , composite material
The bioavailability of an improved formulation of enteric‐coated phenylbutazone with faster dissolution, more consistent in vitro rate of drug release and improved stability was compared in 8 normal subjects at doses of 100 and 200 mg with commercially available Butacote®. Phenylbutazone was more rapidly absorbed from the new formulation and higher plasma concentrations were achieved at shorter intervals after dosing. Drug elimination rate was unaffected by reformulation and despite faster absorption the total amounts of drug reaching the circulation from the new and commercial products were similar. It was concluded that replacing Butacote® by the new formulation would provide the same therapeutic benefit.