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Quantitation of iprindole in plasma by GLC
Author(s) -
Caillé G.,
De Montigny C.,
Besner JG.
Publication year - 1982
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510030103
Subject(s) - chemistry , oral administration , chromatography , pharmacology , plasma concentration , plasma levels , medicine
A specific, sensitive, rapid, and reproducible method for iprindole in human plasma was developed using gas chromatography with trimipramine as internal standard. The sensitivity of the method is of S ng ml −1 and a linearity was obtained for concentrations ranging from 12.5ngml −1 to 100ngml −1 with a regression coefficient of 0.9872. The plasma levels of iprindole were determined in five healthy volunteers following the administration of a single oral dose of 60 mg and in four patients admitted for endogenous depression after a 3‐week administration of 90mgd −1 . Following a single oral dose to healthy volunteers, the maximum concentrations occurred between 2 and 4h after administration of the drug and the mean half‐life value was 52.5 h. In patients the steady‐state concentrations of iprindole ranged between 18 and 77ngml −1 .