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Pharmacokinetics of cefoxitin administered intramuscularly to rabbits with experimentally‐induced renal impairment
Author(s) -
Garcia M. J.,
DominguezGil A. A.,
Cepeda M.,
DominguezGil A.
Publication year - 1981
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510020302
Subject(s) - pharmacokinetics , cefoxitin , medicine , pharmacology , biology , staphylococcus aureus , bacteria , genetics
The pharmacokinetics of Cefoxitin were studied in rabbits with normal renal function and with varying degrees of renal impairment induced experimentally by uranyl nitrate. All animals received a single intramuscular (i.m.) dose of 40 mg kg −1 of the antibiotic. The concentrations of Cefoxitin were determined in plasma, urine, and bile by a microbiologic plate diffusion method. The antibiotic follows a two‐compartment open kinetic model. In rabbits with renal impairment there is a decrease in α, β K 12 , K 12 , K a and an increase in V d and the (AUC) 0 ∞with respect to the values obtained for rabbits with normal renal function. Linear relationships are established between log β and logK 13 and the serum creatinine. Biliary excretion of Cefoxitin is increased in states of renal impairment. A linear relationship is established between the percentage of the dose excreted in bile and the serum creatinine.