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Rectal infusion of the model drug antipyrine with an osmotic delivery system
Author(s) -
De Leede L. G. J.,
De Boer A. G.,
Breimer D. D.
Publication year - 1981
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510020205
Subject(s) - suppository , rectum , drug delivery , pharmacokinetics , rectal administration , drug , saliva , delivery system , defecation , pharmacology , medicine , chemistry , anesthesia , organic chemistry
An osmotically‐powered rectal drug delivery system, was used for the rectal infusion of the model drug antipyrine. The system, which is slightly larger than a normal suppository, has a nominal pumping rate of 43 μl h − 1 over at least 30 h. Four healthy volunteers kept two such systems in their rectum for a sum total of 98 h. Saliva and plasma concentrations were determined at regular intervals and in all cases a very constant steady‐state saliva and plasma concentration was reached and maintained. Defecation and reinsertion of the drug delivery system did not cause any irregularities in the concentration profile. The system was very well tolerated by the volunteers.