Premium
Isoniazid‐induced intolerance to ethanol in rabbit, guinea pig and rat
Author(s) -
Whitehouse L. W.,
Paul C. J.,
Thomas B. H.
Publication year - 1980
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510010503
Subject(s) - isoniazid , ethanol , guinea pig , hydrazine (antidepressant) , isonicotinic acid , pharmacology , alcohol , chemistry , alcohol dehydrogenase , biochemistry , medicine , organic chemistry , tuberculosis , pathology , hydrazide
Isoniazid (50 or 100 mg kg −l p.o.) inhibited the elimination of ethanol (0·5, 1·0, and 2·5 g kg −l p.o.) from the plasma of rabbit, guinea pig, and rat. The effect of isoniazid, isonicotinic acid, N‐acetylisoniazid, N‐acetylhydrazine, N,N‐diacetylhydrazine, and hydrazine on the in vitro metabolism of alcohol by rabbit liver alcohol dehydrogenase was examined. Only isoniazid, hydrazine, and acetylisoniazid showed significant inhibitory activity with I 50 's of 17·7, 1·25, and 0·78 mmol 1 −1 respectively. Intolerance to ethanol following isoniazid treatment was attributed to isoniazid inhibition of liver alcohol dehydrogenase.