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Pharmacokinetics of acetylmethadols I: Gas‐liquid chromatographic determination of L ‐α‐acetylmethadol and its major metabolites in plasma
Author(s) -
Tse Francis L. S.,
Welling Peter G.
Publication year - 1980
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510010408
Subject(s) - chromatography , pharmacokinetics , extraction (chemistry) , chemistry , flame ionization detector , electron capture detector , plasma concentration , plasma , therapeutic drug monitoring , gas chromatography , pharmacology , medicine , physics , quantum mechanics
A gas chromatographic method is reported for simultaneously determining acetyl‐methadol, noracetylmethadol, and dinoracetylmethadol in plasma. Minimum detectable concentrations are 10 ng ml −1 for acetylmethadol using a flame ionization detector, and 5 and 25 ng ml −l for noracetylmethadol and dinoracetylmethadol respectively using electron capture detection. Extraction efficiency is quantitative for acetylmethadol but lower for the metabolites. The method is useful for monitoring drug levels following therapeutic doses of acetylmethadol.