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Pharmacokinetic characteristics of two different formulations of trimipramine determined with a new GLC method
Author(s) -
Caillé Gilles,
Besner JeanGuy,
Lacasse Y.,
Vézina M.
Publication year - 1980
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510010406
Subject(s) - bioavailability , pharmacokinetics , chromatography , capsule , chemistry , plasma concentration , pharmacology , medicine , biology , botany
A sensitive and specific gas chromatographic method using a nitrogen detector for the measurement of trimipramine plasma concentrations is described. This method was used to determine the relative bioavailability and some pharmacokinetic parameters of two formulations, tablets and capsules, in healthy volunteers. It was concluded the tablet and capsule formulations were pharmacokinetically equivalent.