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Comparison of two dissolution apparatuses with correlation of in vitro‐in vivo data for prednisone and prednisolone tablets
Author(s) -
Milsap Rebecca L.,
Ayres James W.,
Mackichan Janis J.,
Wagner John G.
Publication year - 1979
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510010103
Subject(s) - in vivo , prednisone , prednisolone , pharmacology , pharmacokinetics , in vitro , chemistry , medicine , mathematics , biochemistry , biology , microbiology and biotechnology
Dissolution profiles in 0‐1N hydrochloric acid using both the paddle stirrer apparatus and the spin filter apparatus were obtained for prednisone tablets made by seven different manufacturers and prednisolone tablets made by eight different manufacturers. Dissolution parameters were correlated with results obtained in three human bioavailability trials which were previously reported. Also, results obtained in one apparatus were correlated with those obtained in the other apparatus. Such correlations may be useful in the setting of in vitro dissolution rate specifications for commercial prednisone and prednisolone tablets.