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Effect of dietary fibers on losartan uptake and transport in Caco‐2 cells
Author(s) -
Iwazaki Ayano,
Takahashi Naho,
Miyake Reiko,
Hiroshima Yuka,
Abe Mariko,
Yasui Airi,
Imai Kimie
Publication year - 2016
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2004
Subject(s) - losartan , chemistry , pharmacology , chitosan , angiotensin ii , sodium , in vitro , endocrinology , biophysics , receptor , medicine , biochemistry , biology , organic chemistry
The objective of this study was to assess the effect of dietary fibers on the transport of losartan, an angiotensin II type 1 receptor blocker, in small intestinal cells. Using Caco‐2 cells in vitro , losartan uptake and transport were evaluated in the presence of various fibers (cellulose, chitosan, sodium alginate and glucomannan). Dietary fibers caused a decrease in the uptake of losartan, with chitosan causing a significant reduction. Chitosan and glucomannan significantly reduced the transport of losartan, while cellulose or sodium alginate did not. Dietary fibers also reduced the level of free losartan; however, this did not correlate with the observed reduction in losartan uptake and transport. In summary, chitosan had the greatest inhibitory effect on losartan uptake and transport, and this potential interaction should be considered in patients taking losartan. Copyright © 2016 John Wiley & Sons, Ltd.