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Application of a method used to deconstruct a single dose pharmacokinetic profile from multiple dose data
Author(s) -
Stockmann Chris,
Spigarelli Michael G.,
Healy Daniel P.,
Gottschlich Michele M.,
Kagan Richard,
Balch Alfred H.,
Sherwin Catherine
Publication year - 2015
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.1949
Subject(s) - pharmacokinetics , dosing , gatifloxacin , pharmacology , medicine , oral dose , mathematics , chemistry , antibiotics , biochemistry , ciprofloxacin
Abstract With traditional non‐compartmental methods, it is challenging to deconstruct plasma concentration versus time curves to assess the influence of individual doses. This study describes the application of a mathematical approach used to deconstruct a single dose curve using data derived from the second, third, fourth or n th dosing interval. Using data from a prospective clinical trial it is demonstrated that this approach reliably estimates pharmacokinetic parameters measured following two doses of zolpidem tartrate. Additionally, the study demonstrates the application of this approach using previously published data from a single‐ and multiple‐dose pharmacokinetic study of the antibiotic gatifloxacin. Copyright © 2015 John Wiley & Sons, Ltd.