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Pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats
Author(s) -
Wang Fugang,
Cao Juan,
Hao Jifu,
Liu Ke
Publication year - 2014
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.1869
Subject(s) - bioavailability , pharmacokinetics , pharmacology , oral administration , distribution (mathematics) , tissue distribution , chemistry , high performance liquid chromatography , kidney , medicine , chromatography , mathematical analysis , mathematics
In order to characterize the pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats, a reliable gradient HPLC‐based method has been developed and validated. After p.o. administration of geniposide, the peak concentration of geniposide in plasma occurred at 1 h and plasma geniposide was eliminated nearly completely within 12 h. The AUC 0→ ∞ values of geniposide were 6.99 ± 1.27 h · µg/ml and 6.76 ± 1.23 h · µg/ml after i.v. administration of 10 mg/kg and p.o. administration of 100 mg/kg of geniposide, respectively. The absolute oral bioavailability (% F ) of geniposide was calculated as 9.67%. After p.o. administration of geniposide, the AUC 0→4h values in tissues were in the order of kidney > spleen > liver > heart > lung > brain. This study improved the understanding of the pharmacokinetics, bioavailability and tissue distribution of geniposide in rats and may provide a meaningful basis for clinical application of such a bioactive compound of herbal medicines. Copyright © 2013 John Wiley & Sons, Ltd.