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Effect of organic ligands with conjugated π‐bonds on the structure of iodine–α‐dextrin complexes
Author(s) -
Yuldasheva Gulnara A.,
Zhidomirov Georgii M.,
Ilin Aleksandr I.
Publication year - 2012
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.70
Subject(s) - dextrin , chemistry , lithium (medication) , iodine , conjugated system , dna , molecule , crystallography , stereochemistry , organic chemistry , polymer , biochemistry , biology , starch , endocrinology
Using X‐ray data for iodine–α‐dextrin complexes and the results of quantum chemical ab initio restricted Hartree–Fock/3‐21G ** level calculations, a model of drug active complex (AC) Armenicum with anti‐HIV action was proposed. It was suggested that the drug AC contains molecular iodine allocated inside of α‐dextrin helix and coordinated by lithium halogenides and a protein component of lymphocyte ribosomes. The electronic structure of I 2 in this complex differs from its characteristics in complexes with organic ligands or the free I 2 . In the considered ACs, the molecular iodine displays acceptor (donor) properties toward the α‐dextrins (lithium halogenides). A mechanism of Armenicum anti‐HIV action is suggested. Under the influence of molecular iodine‐containing drug AC, the structure of HIV DNA is modified—it becomes more π‐donor‐active against proteins and peptide nucleotides of viral DNA form a stable complex with molecular iodine and lithium halogenides.