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Relationship between Sphk1/S1P and microRNAs in human cancers
Author(s) -
Khoei Saeideh Gholamzadeh,
Sadeghi Hamid,
Samadi Pouria,
Najafi Rezvan,
Saidijam Massoud
Publication year - 2021
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1922
Subject(s) - microrna , sphingosine kinase 1 , sphingosine 1 phosphate , metastasis , carcinogenesis , sphingosine , biology , angiogenesis , cancer , kinase , sphingosine kinase , cancer research , downregulation and upregulation , cell growth , microbiology and biotechnology , genetics , gene , receptor
Abstract Sphingosine kinases type 1 ( SphK1 ) is a key enzyme in the phosphorylation of sphingosine to sphingosine 1‐phosphate (S1P). Different abnormalities in SphK1 functions may correspond with poor prognosis in various cancers. Additionally, upregulated SphK1 /S1P could promote cancer cell proliferation, angiogenesis, mobility, invasion, and metastasis. MicroRNAs as conserved small noncoding RNAs play major roles in cancer initiation, progression, metastasis, etc. Their posttranscriptionally mechanisms could affect the development of cancer growth or tumorigenesis suppression. The growing number of studies has described that various microRNAs can be regulated by SphK1 , and its expression level can also be regulated by microRNAs. In this review, the relationship of SphK1 and microRNA functions and their interaction in human malignancies have been discussed. Based on them novel treatment strategies can be introduced.