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MicroRNA‐218 inhibits type I interferon production and facilitates virus immune evasion via targeting RIG‐I
Author(s) -
Qiu Yongle,
Geng Xixue,
Ban Jiandong,
Liu Yuanhang
Publication year - 2020
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1882
Subject(s) - biology , immune system , rig i , interferon , microrna , virology , evasion (ethics) , virus , immunity , small interfering rna , rna interference , interferon type i , signal transduction , microbiology and biotechnology , rna , gene , innate immune system , immunology , genetics
The host protective immunity against viral infection requires the effective detection of viral antigens and the subsequent production of type I interferons (IFNs) by host immune cells. Retinoic acid‐inducible gene I (RIG‐I) is the crucial signaling element responsible for sensing viral RNA component and initiating the downstream antiviral signaling pathways, leading to the production of type I IFNs. In this work, we identified microRNA‐218 (miR‐218) as a new virus‐induced miRNA that dampens the expression of RIG‐I in mouse and human macrophages, leading to the impaired production of type I IFNs. Interfering miR‐218 expression rescued RIG‐I‐mediated antiviral signaling and thus protected macrophages from viral infection. Hence, our results provide new understanding of miRNA‐mediated viral immune evasion and may be potentially useful for the treatment of viral infection in the future.