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Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension
Author(s) -
Singh Yogendra,
Samuel Vijaya Paul,
Dahiya Sunita,
Gupta Gaurav,
Gillhotra Ritu,
Mishra Anurag,
Singh Mahaveer,
SreeHarsha Nagaraja,
Gubbiyappa Shiva Kumar,
Tambuwala Murtaza M.,
Chellappan Dinesh Kumar,
Dua Kamal
Publication year - 2019
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1799
Subject(s) - hyperhomocysteinemia , olmesartan , homocysteine , uric acid , medicine , creatinine , blood pressure , angiotensin converting enzyme , endocrinology , methionine , angiotensin ii , pharmacology , chemistry , biochemistry , amino acid
Homocysteine [HSCH 2 CH 2 CH(NH 2 )COOH] (Hcy) is a sulfur‐containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, that is usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta‐analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin‐converting enzyme inhibitors angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia‐associated hypertension.