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Matrilin‐2 prevents the TNFα‐induced apoptosis of WB‐F344 cells via suppressing JNK pathway
Author(s) -
Luo Junming,
Peng Shaohua,
Bai Wenbin,
Wu Zhaoyu,
Shan Zhongshu,
Wu Zetao,
Yuan Xin,
Che Xiaoming,
Duan Zhili,
Peng Jinwu,
Wang Yichun,
Zhang Shukun
Publication year - 2019
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1726
Subject(s) - tumor necrosis factor alpha , apoptosis , microbiology and biotechnology , inflammation , necrosis , cancer research , cell , progenitor cell , chemistry , biology , immunology , medicine , stem cell , biochemistry
Oval cells, a kind of hepatic progenitor cell quiescent at normal condition, activates to proliferate and differentiate into hepatocytes under severe and long‐term liver injury, which usually raises severe inflammation. However, how oval cell survives in the inflammatory milieu interne is still unclear. Tumor necrosis factor α (TNFα), mimicking inflammatory hepatic milieu interne, was used to treat oval cell line, WB‐F344, to test the protective function of matrilin‐2. In this study, our data suggested that matrilin‐2 prevented TNFα‐induced apoptosis in WB‐F344 cells via inhibiting ASK1/MKK7/JNK pathway. In conclusion, we determined that matrilin‐2 plays the key role in maintaining the survival of oval cell and guarantees its proliferation under various injury factors.