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Employment of fucosidases for the synthesis of fucosylated oligosaccharides with biological potential
Author(s) -
GuzmánRodríguez Francisco,
AlatorreSantamaría Sergio,
GómezRuiz Lorena,
RodríguezSerrano Gabriela,
GarcíaGaribay Mariano,
CruzGuerrero Alma
Publication year - 2018
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1714
Subject(s) - cleave , biochemistry , oligosaccharide , enzyme , biology , chemistry
Fucosylated oligosaccharides play important physiological roles in humans, including in the immune response, transduction of signals, early embryogenesis and development, growth regulation, apoptosis, pathogen adhesion, and so on. Efforts have been made to synthesize fucosylated oligosaccharides, as it is difficult to purify them from their natural sources, such as human milk, epithelial tissue, blood, and so on. Within the strategies for its in vitro synthesis, it is remarkable the employment of fucosidases, enzymes that normally cleave the fucosyl residue from the non‐reducing end of fucosylated compounds, as these enzymes are also capable of synthesizing them by means of a transfucosylation reaction. This review summarizes the progress in the use of fucosidases for the synthesis of compounds that have potential for industrial and commercial applications.