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Novel bioactive porous starch–siloxane matrix for bone regeneration: Physicochemical, mechanical, and in vitro properties
Author(s) -
Aidun Amir,
Zamanian Ali,
Ghorbani Farnaz
Publication year - 2018
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1694
Subject(s) - starch , chemical engineering , scaffold , biodegradation , tissue engineering , porosity , scanning electron microscope , chemistry , mineralization (soil science) , absorption of water , microstructure , materials science , bone tissue , biomedical engineering , composite material , organic chemistry , medicine , nitrogen , engineering
So far, many studies have focused on biodegradable scaffolds for tissue engineering purposes. Herein, a starch‐based biodegradable scaffold was fabricated by the freeze‐drying method and cross‐linked using a different concentration of 3‐glycidoxypropyl‐trimethoxysilane (GPTMS). Field emission scanning electron microscopy (FE‐SEM) micrographs indicated an interconnected porous microstructure in which the porosity decreased as a function of starch and GPTMS content. Increasing the mechanical stability and decreasing absorption capacity and biodegradation ratio affected by the higher concentration of cross‐linker and the changes in structure as a function of cross‐linker enhancement. Moreover, the mineralization of hybrid structures in simulated body fluid was proved by FE‐SEM image and X‐ray diffraction analysis. Results indicated the more GPTMS in scaffolds led to more hydroxyapatite formation. The ability of the growth and proliferation of bone marrow mesenchyme stem cells on the constructs confirmed the ability of scaffolds for bone tissue engineering applications.