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Structural modeling of tumor necrosis factor: A protein of immunological importance
Author(s) -
Roy Urmi
Publication year - 2017
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1523
Subject(s) - tumor necrosis factor alpha , cytokine , microbiology and biotechnology , receptor , biology , mutant , programmed cell death , protein structure , signal transduction , computational biology , chemistry , apoptosis , immunology , genetics , biochemistry , gene
Tumor necrosis factor (TNF) is a multifunctional pro‐inflammatory cytokine responsible for various immunoregulatory activities. Upon binding with its receptor, TNF triggers multiple complex signaling pathways such as the activations of nuclear factor kappa B and caspase cascade, which are the leading determining factors for cell survival or cell death. The present work studies certain modeling aspects of the TNF, with comparative structural analyses of the wild and mutant types of this protein. Additionally, nanoscale molecular dynamics simulations are performed to assess the structure–property relationships of proteins as functions of time.