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The cytochrome P 450 complement ( CYP ome) of Mycosphaerella graminicola
Author(s) -
Newsome Alun W.,
Nelson David,
Corran Andrew,
Kelly Steven L.,
Kelly Diane E.
Publication year - 2013
Publication title -
biotechnology and applied biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 70
eISSN - 1470-8744
pISSN - 0885-4513
DOI - 10.1002/bab.1062
Subject(s) - mycosphaerella graminicola , graminicola , biology , lanosterol , cytochrome p450 , azole , ergosterol , genetics , gene , computational biology , botany , biochemistry , microbiology and biotechnology , antifungal , enzyme , sterol , cholesterol
Abstract Mycosphaerella graminicola is a key fungal pathogen of wheat and a major target for azole fungicides, many of whose central mode of action is through inhibition of cytochrome P450 51 (lanosterol 14α‐demethylase) in the ergosterol biosynthetic pathway. The range of activities of other fungal CYP s is thought to be a reflection of the differences between different organisms and their range of secondary metabolic pathways as a response to their niche environments, for example, in the production of mycotoxins. The present study collates information from a range of databases, to classify the CYP s found in M. graminicola and assign them an internationally recognized nomenclature, which, when referenced to the recent publication of the JGI version 2.0 genome model, creates a current, robust model for the CYP complement ( CYP ome) of M. graminicola . These CYP ome data, which examined 82 CYP s and one pseudo‐gene, may be utilized not only to further characterize and describe the physiology of the organism but also to enhance our understanding of CYP function and diversity.