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Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study
Author(s) -
Lyall Kristen,
Van de Water Judy,
Ashwood Paul,
HertzPicciotto Irva
Publication year - 2015
Publication title -
autism research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 66
eISSN - 1939-3806
pISSN - 1939-3792
DOI - 10.1002/aur.1471
Subject(s) - autism , allergy , asthma , medicine , autism spectrum disorder , odds ratio , confidence interval , pediatrics , psychiatry , immunology
Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors. Autism Res 2015, 8: 567–574 . © 2015 International Society for Autism Research, Wiley Periodicals, Inc.