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I 2 ‐Promoted Intramolecular Oxidative Cyclization of Butenyl Anilines: A Facile Route to Benzo[ b ]azepines
Author(s) -
An Zhenyu,
Ren Yi,
Liu Yafeng,
Yan Rulong
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100710
Subject(s) - azepine , intramolecular force , chemistry , annulation , oxidative coupling of methane , medicinal chemistry , functional group , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , polymer
A metal‐free approach for the synthesis of seven‐membered N ‐heterocycles has been developed by the I 2 ‐promoted intramolecular cross‐coupling/annulation of butenyl anilines. This cyclization reaction involves C−H activation and C−C bond formation and exhibits good functional group tolerance. A series of benzo[ b ]azepine derivatives are obtained in moderate to good yields.