I 2 ‐Promoted Intramolecular Oxidative Cyclization of Butenyl Anilines: A Facile Route to Benzo[ b ]azepines | Zendy

An Zhenyu | Zendy; Ren Yi | Zendy; Liu Yafeng | Zendy; Yan Rulong | Zendy

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I 2 ‐Promoted Intramolecular Oxidative Cyclization of Butenyl Anilines: A Facile Route to Benzo[ b ]azepines

Author(s) -

An Zhenyu,

Ren Yi,

Liu Yafeng,

Yan Rulong

Publication year - 2021

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.202100710

Subject(s) - azepine , intramolecular force , chemistry , annulation , oxidative coupling of methane , medicinal chemistry , functional group , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , polymer

A metal‐free approach for the synthesis of seven‐membered N ‐heterocycles has been developed by the I 2 ‐promoted intramolecular cross‐coupling/annulation of butenyl anilines. This cyclization reaction involves C−H activation and C−C bond formation and exhibits good functional group tolerance. A series of benzo[ b ]azepine derivatives are obtained in moderate to good yields.

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