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Visible‐Light‐Driven Sulfonylation/Cyclization to Access Sulfonylated Benzo[4,5]imidazo[2,1‐ a ]isoquinolin‐6(5 H )‐ones
Author(s) -
Wang Chen,
Sun Guoquan,
Huang HongLi,
Liu Jing,
Tang Hua,
Li Yinghua,
Hu Honggang,
He Shipeng,
Gao Fei
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100681
Subject(s) - reagent , chemistry , sulfonyl , chloride , combinatorial chemistry , visible spectrum , medicinal chemistry , organic chemistry , optoelectronics , materials science , alkyl
Abstract Visible‐light‐driven sulfonylation/cyclization of N ‐methacryloyl‐2‐phenylbenzoimidazoles has been successfully developed. Using commercially available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo[4,5]imidazo[2,1‐ a ]isoquinolin‐6(5 H )‐ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds.