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Nickel‐Catalyzed Cross‐Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides
Author(s) -
Li Han,
Sheng Jie,
Wu BingBing,
Li Yan,
Wang XiSheng
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100348
Subject(s) - nickel , aryl , catalysis , phosphine , chemistry , regent , zinc , coupling reaction , organic chemistry , combinatorial chemistry , microbiology and biotechnology , biology , alkyl
A combinatorial nickel‐catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent ethyl chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process.