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Palladium/Zinc Co‐Catalyzed Asymmetric Hydrogenation of γ‐Keto Carboxylic Acids
Author(s) -
Zhang Keyang,
Zhang Xuexin,
Chen Jingchao,
Liu Zixiu,
Pan Chunxiang,
Zhu Yuanbin,
Wu Shiyuan,
Fan Baomin
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100244
Subject(s) - palladium , catalysis , levulinic acid , ketone , chemistry , zinc , asymmetric hydrogenation , carboxylic acid , organic chemistry , noyori asymmetric hydrogenation , enantioselective synthesis
A palladium‐catalyzed asymmetric hydrogenation of levulinic acid has been successful developed by using Zn(OTf) 2 as co‐catalyst. The present method not only has provided a strategy in the palladium‐catalyzed asymmetric hydrogenation of ketone, but also allowed the preparation of a wide range of chiral γ‐valerolactones in good yields with excellent enantioselectivities.