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Ultrasound‐Enhanced Self‐Exciting Photodynamic Therapy Based on Hypocrellin B
Author(s) -
Ding Ying,
Liu Weimin,
Wu Jiasheng,
Zheng Xiuli,
Ge Jiechao,
Ren Haohui,
Zhang Wenjun,
Lee ChunSing,
Wang Pengfei
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100205
Subject(s) - photodynamic therapy , peroxyoxalate , sonodynamic therapy , chemiluminescence , light source , nanotechnology , medicine , dermatology , materials science , chemistry , optics , physics , chromatography , organic chemistry
Peroxalate CL as an energy source to excite photosensitizers has attracted tremendous attention in photodynamic therapy (PDT). In this work, peroxyoxalate CPPO and hypocrellin B (HB)‐based nanoparticles (CBNPs) for ultrasound (US)‐enhanced self‐exciting PDT were designed and prepared. CBNPs showed an excellent therapeutic effect against cancer cells with the assistance of US. This US‐enhanced‐chemiluminescence system avoids the dependence on external light and provides an example for inspiring more effective and precise strategies for cancer treatment.