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A Base‐Mediated Approach Towards Dihydrofuro[2,3‐ b ]Benzofurans from 2‐Nitrobenzofurans and 1,3‐Dicarbonyls
Author(s) -
Singh Gurdeep,
Pandey Rajat,
Kurup Adarsh S.,
Anand Ramasamy Vijaya
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100184
Subject(s) - benzofuran , chemistry , intramolecular force , base (topology) , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , mathematics , mathematical analysis
A straight‐forward approach for the synthesis of a dihydrofuro[2,3‐ b ]benzofuran derivatives has been achieved through a base‐mediated Michael addition of 1,3‐dicarbonyls to 2‐nitrobenzofurans followed by intramolecular cyclization. A variety of 1,3‐dicarbonyls, including cyclic as well as trifluoromethylated ones, have been subjected to react with 2‐nitrobenzofurans under optimal conditions, and the respective dihydrofuro[2,3‐ b ]benzofurans could be accessed in moderate to excellent yields.