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A New Potent Antimicrobial Metalloporphyrin
Author(s) -
Jiang Lu,
Chee Pei Lin,
Gao Jian,
Gan Ching Ruey Raymond,
Owh Cally,
Lakshminarayanan Rajamani,
Jiang Shan,
Hor T. S. Andy,
Loh Xian Jun
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202100053
Subject(s) - antimicrobial , cytotoxicity , porphyrin , chemistry , bacteria , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , in vitro , biology , genetics
A series of bis ‐acryl functionalized porphyrins and their corresponding metalloporphyrins (M=Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time‐kill kinetic studies. The Mn(III) 4‐(bis)methylphenyl‐substituted‐porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile.