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Palladium Catalyzed Cascade Azidation/Carbonylation of Aryl Halides with Sodium Azide for the Synthesis of Amides
Author(s) -
Qi Zhuang,
Li ShanShan,
Li Lin,
Qin Qi,
Yang LiMiao,
Liang YingKang,
Kang Yun,
Zhang XiangZhi,
Ma AiJun,
Peng JinBao
Publication year - 2021
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202001463
Subject(s) - carbonylation , chemistry , aryl , palladium , catalysis , sodium azide , amide , xantphos , organic chemistry , halide , bromobenzene , combinatorial chemistry , alkyl , carbon monoxide
Amide synthesis is one of the most important transformations in organic chemistry due to their ubiquitous presence in our daily life. In this communication, a palladium catalyzed cascade azidation/carbonylation of aryl halides for the synthesis of amides was developed. Both iodo‐ and bromobenzene derivatives were transformed to the corresponding amides using PdCl 2 /xantphos as the catalyst system and sodium azide as the nitrogen‐source. The reaction proceeds via a cascade azidation/carbonylation process. A range of alkyl and halogen substituted amides were prepared in moderate to good yields.