The Emergence of Palladium‐Catalyzed C(sp 3 )−H Functionalization of Free Carboxylic Acids | Zendy

Das Animesh | Zendy; Maji Biplab | Zendy

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The Emergence of Palladium‐Catalyzed C(sp 3 )−H Functionalization of Free Carboxylic Acids

Author(s) -

Das Animesh,

Maji Biplab

Publication year - 2021

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.202001440

Subject(s) - palladium , surface modification , moiety , chemistry , carboxylate , regioselectivity , catalysis , reactivity (psychology) , denticity , combinatorial chemistry , carboxylic acid , organic chemistry , crystal structure , medicine , alternative medicine , pathology

Palladium‐catalyzed directing group assisted C−H bond activation has emerged as a powerful tool in synthetic organic chemistry. However, only recently, among various directing groups, widely available carboxylate moiety is recognized as a versatile candidate for the regioselective transformations. Notably, palladium‐catalyzed carboxylate directed C(sp 3 )−H bond activation and diverse functionalization is highly challenging and has gained huge attention for its versatile applications. Mono‐ and bidentate ligands have proven to be useful for accelerating the C(sp 3 )−H bond activation step, which helps to control reactivity and selectivity (including enantioselectivity). In this Minireview, we discuss the recent progress made in palladium‐catalyzed C(sp 3 )−H bond functionalization reactions for the construction of C−C and C−Heteroatom bonds with the direction of free carboxylic acid.

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