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Front Cover: Rapid Access to Dispirocyclic Scaffolds Enabled by Diastereoselective Intramolecular Double Functionalization of Benzene Rings (Chem. Asian J. 24/2020)
Author(s) -
Yokoe Hiromasa,
Mizumura Yuka,
Sugiyama Kana,
Yan Kejia,
Hashizume Yuna,
Endo Yuto,
Yoshida Sae,
Kiriyama Akiko,
Tsubuki Masayoshi,
Kanoh Naoki
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202001313
Subject(s) - intramolecular force , reagent , benzene , aromaticity , domino , surface modification , combinatorial chemistry , molecule , chemistry , solvent , materials science , stereochemistry , organic chemistry , catalysis
There is an Asian legend in which a fish climbs over a waterfall and turns into a dragon. In this study, domino double spirocyclization occurred over the high energy barrier arising from the aromaticity. The key reagents were Ag salt, N ‐iodosuccinimide (NIS), and 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) solvent, whose names are hidden in the picture. These reagents transformed simple molecules into complex 3D architectures. More information can be found in the Communication by Hiromasa Yokoe, Naoki Kanoh et al.