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Electrochemical Oxidative Cross‐Coupling of Enaminones and Thiophenols to Construct C−S Bonds
Author(s) -
Lu Fangling,
Zhang Kan,
Wang Xiaoyu,
Yao Yanxiu,
Li Liangsen,
Hu Jianguo,
Lu Lijun,
Gao Ziwei,
Lei Aiwen
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202001116
Subject(s) - electrochemistry , yield (engineering) , sulfur , catalysis , chemistry , molecule , oxidative coupling of methane , combinatorial chemistry , organic chemistry , materials science , electrode , metallurgy
An electrochemical oxidative C(sp 2 )‐H sulfuration has been developed. Various enaminones and thiophenols were compatible, generating the desired alkenyl sulfur compounds in up to 87 % yield. This transformation proceeded smoothly under mild reaction conditions without external oxidant and transition‐metal catalyst. Remarkably, thiophenols selectively coupled with enamines when substrates had other alkenyl groups. In addition, the desired products could be further transformed into a series of α‐sulfur isoxazoles, which are a kind of useful heterocycles in materials and bioactive molecules.