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Near‐Infrared Hypocrellin Derivatives for Synergistic Photodynamic and Photothermal Therapy
Author(s) -
Ding Ying,
Liu Weimin,
Wu Jiasheng,
Zheng Xiuli,
Ge Jiechao,
Ren Haohui,
Zhang Wenjun,
Lee ChunSing,
Wang Pengfei
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202000911
Subject(s) - photothermal therapy , singlet oxygen , photodynamic therapy , peg ratio , absorption (acoustics) , chemistry , solubility , in vivo , near infrared spectroscopy , photochemistry , materials science , nuclear chemistry , nanotechnology , organic chemistry , oxygen , optics , biology , physics , microbiology and biotechnology , finance , economics , composite material
Hypocrellin B (HB) derived from naturally produced hypocrellins has attracted considerable attention in photodynamic therapy (PDT) because of its excellent photosensitive properties. However, the weak absorption within a “phototherapy window” (600–900 nm) and poor water solubility of HB have limited its clinical application. In this study, two HB derivatives (i. e., HE and HF ) were designed and synthesized for the first time by introducing two different substituent groups into the HB structure. The obtained derivatives showed a broad absorption band covering the near‐infrared (NIR) region, NIR emission (peaked at 805 nm), and singlet oxygen quantum yields of 0.27/0.31. HE‐PEG‐NPs were also prepared using 2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethyleneglycol)‐2000] (DSPE‐mPEG2000) to achieve excellent dispersion in water and further explored their practical applications. HE‐PEG‐NPs not only retained their 1 O 2 ‐generating ability, but also exhibited a photothermal conversion efficiency of 25.9%. In vitro and in vivo therapeutic results revealed that the synergetic effect of HE‐PEG‐NPs on PDT and photothermal therapy (PTT) could achieve a good performance. Therefore, HE‐PEG‐NPs could be regarded as a promising phototheranostic agent.