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Phenoxazine‐based Near‐infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells
Author(s) -
Shen Yang,
Zheng Wubin,
Yao Yusi,
Wang Dongmei,
Lv Guanglei,
Li Chunxia
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202000783
Subject(s) - copper , phenoxazine , fluorescence , detection limit , ion , chemistry , selectivity , quenching (fluorescence) , photochemistry , inorganic chemistry , analytical chemistry (journal) , chromatography , optics , organic chemistry , catalysis , medicine , physics , phenothiazine , pharmacology
Abstract : It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are “turn‐off” probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel “turn‐on” near‐infrared (NIR) fluorescent probe PZ‐N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu 2+ ). Upon the addition of Cu 2+ , the probe could quickly react with Cu 2+ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ‐N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ‐N was capable of effectively detecting Cu 2+ in living cells.