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Front Cover: Incorporation of Pseudo‐complementary Bases 2,6‐Diaminopurine and 2‐Thiouracil into Serinol Nucleic Acid (SNA) to Promote SNA/RNA Hybridization (Chem. Asian J. 8/2020)
Author(s) -
Kamiya Yukiko,
Sato Fuminori,
Murayama Keiji,
Kodama Atsuji,
Uchiyama Susumu,
Asanuma Hiroyuki
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202000223
Subject(s) - nucleic acid , rna , chemistry , nucleic acid thermodynamics , thiouracil , dna , biochemistry , stereochemistry , genetics , biology , gene , thyroid
Serinol nucleic acid (SNA) is promising for nucleic acid‐based drugs due to its affinity to RNA. However, stable self‐hybridization of SNA in short complementary regions hinders hetero‐hybridization with RNA. It is thus crucial to suppress self‐hybridization for promoting SNA‐RNA hybridization. Herein, suitable protocols were developed for the preparation of SNA containing 2,6‐diaminopurine (D) and 2‐thiouracil (sU) pairs in which SNA‐D causes steric hindrance with SNA‐sU but makes three hydrogen bonds with RNA‐U. Incorporation of D‐sU in a palindromic sequence of SNA promotes selective and stable hybridization with complementary RNA by preventing the self‐hybridization of SNA. More information can be found in the Communication by Yukiko Kamiya, Hiroyuki Asanuma et al. on page 1266 in Issue 8, 2020 (DOI: 10.1002/asia.201901728).