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Development of Stimulus‐Responsive Degradable Film via Codeposition of Dopamine and Cystamine
Author(s) -
Jeong Wonwoo,
Kim Eunseok,
Jeong Jaehoon,
Bisht Himani,
Kang Hyeongeun,
Hong Daewha
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202000216
Subject(s) - cystamine , tcep , phosphine , materials science , chemistry , tris , combinatorial chemistry , chemical engineering , nanotechnology , organic chemistry , catalysis , biochemistry , engineering
Herein, we report a degradable film that can be coated on various substrates by the codeposition of dopamine and cystamine. The thickness of the resulting film (pDC) varies depending on the initial ratio of dopamine/cystamine dissolved in a solution; the thickest film (ca. 60 nm) is obtained under optimized codeposition conditions. Selective degradation of pDC occurs in the presence of tris(2‐carboxyethyl)phosphine (TCEP), the reaction kinetics of which are highly dependent on the TCEP concentration. For further application as a drug‐delivery platform, doxorubicin can be loaded within the pDC film, which is released actively under film degradation in response to TCEP. We expect that the developed pDC film will be a useful tool for developing drug delivery cargo, antibacterial surface, and cell surface coating for various biomedical applications.