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Non‐Heme‐Type Ruthenium Catalyzed Chemo‐ and Site‐Selective C−H Oxidation
Author(s) -
Doiuchi Daiki,
Nakamura Tatsuya,
Hayashi Hiroki,
Uchida Tatsuya
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202000134
Subject(s) - ruthenium , chemistry , catalysis , steric effects , ketone , ligand (biochemistry) , amide , amine gas treating , heme , tris , methylene , alcohol oxidation , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , enzyme , biochemistry , receptor
Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo‐ and site‐selective C−H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2‐pyridylmethyl)amine with an electron‐donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo‐, and site‐selectivities were observed for reactions using the cis ‐ruthenium complex rather than the trans ‐one. This reaction could be used to convert sterically less hindered methyne and/or methylene C−H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.