Rh(III)‐Catalyzed Denitrogenative [4+2] Annulation of Benzamides and 3‐Diazoindolin‐2‐imines: Expedient Access to Indolo[2,3‐ c ] isoquinolin‐5‐ones | Zendy

Pal Kuntal | Zendy; Adak Souvik | Zendy; Dey Arnab | Zendy; Volla Chandra M. R. | Zendy

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Rh(III)‐Catalyzed Denitrogenative [4+2] Annulation of Benzamides and 3‐Diazoindolin‐2‐imines: Expedient Access to Indolo[2,3‐ c ] isoquinolin‐5‐ones

Author(s) -

Pal Kuntal,

Adak Souvik,

Dey Arnab,

Volla Chandra M. R.

Publication year - 2020

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.202000096

Subject(s) - annulation , catalysis , chemistry , combinatorial chemistry , substrate (aquarium) , scope (computer science) , reaction conditions , stereochemistry , medicinal chemistry , organic chemistry , computer science , biology , ecology , programming language

An effective and pragmatic strategy for the synthesis of structurally diverse indolo[2,3‐ c ]isoquinolin‐5‐ones has been developed via a Rh(III)‐catalyzed C−H activation and [4+2] annulation reaction of N ‐methoxybenzamides and 3‐diazoindolin‐2‐imines. The reaction involves the efficient formation of two new (one C−C and one C−N) bonds under operationally simple conditions and has the benefits of a broad substrate scope.

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