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Reversed Cation Selectivity of G 8 ‐Octamer and G 16 ‐Hexadecamer towards Monovalent and Divalent Cations
Author(s) -
He Ying,
Zhang Yanbin,
Wojtas Lukasz,
Akhmedov Novruz G.,
Pan Qinhe,
Guo Hao,
Shi Xiaodong
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.202000016
Subject(s) - divalent , selectivity , chemistry , histone octamer , inorganic chemistry , divalent metal , crystallography , biochemistry , catalysis , gene , organic chemistry , histone , metal , nucleosome
A reverse‐binding‐selectivity between monovalent and divalent cations was observed for two different self‐assembly G 16 ‐hexadecamer and G 8 ‐octamer systems. The dissociation constant between G 4 ‐quadruplex and monomer was calculated via VT‐ 1 H NMR experiments. Quantitative energy profiles revealed entropy as the key factor for the weaker binding toward Ba 2+ compared with K + in the G 8 ‐octamer system despite stronger ion‐dipole interactions. This study is the first direct comparison of the G 4 ‐quartet binding affinity between mono and divalent cations and will benefit future applications of G‐quadruplex‐related research. Further competition experiments between the G 8 ‐octamer and 18‐crown‐6 with K + demonstrated the potential of this G 8 system as a new potassium receptor.