Palladium‐Catalyzed Decarboxylative  ortho ‐C(sp 2 )−H Aroylation of  N ‐Sulfoximine Benzamides at Room Temperature | Zendy

Das Prasenjit | Zendy; Biswas Promita | Zendy; Guin Joyram | Zendy

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Palladium‐Catalyzed Decarboxylative ortho ‐C(sp 2 )−H Aroylation of N ‐Sulfoximine Benzamides at Room Temperature

Author(s) -

Das Prasenjit,

Biswas Promita,

Guin Joyram

Publication year - 2020

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201901759

Subject(s) - palladium , catalysis , acylation , chemistry , medicinal chemistry , decarboxylation , catalytic cycle , organic chemistry

A palladium‐catalyzed method for the decarboxylative ortho C−H acylation of N ‐sulfoximine benzamides is developed at room temperature. The catalytic method enables easy access to various functionalized 2‐aroylaromatic carboxylic acid derivatives in good isolated yields. Based on our mechanistic studies, a Pd(II)/Pd(IV) catalytic cycle that involves aroyl radical intermediate is proposed for the reaction.

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