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Palladium‐Catalyzed Decarboxylative ortho ‐C(sp 2 )−H Aroylation of N ‐Sulfoximine Benzamides at Room Temperature
Author(s) -
Das Prasenjit,
Biswas Promita,
Guin Joyram
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901759
Subject(s) - palladium , catalysis , acylation , chemistry , medicinal chemistry , decarboxylation , catalytic cycle , organic chemistry
A palladium‐catalyzed method for the decarboxylative ortho C−H acylation of N ‐sulfoximine benzamides is developed at room temperature. The catalytic method enables easy access to various functionalized 2‐aroylaromatic carboxylic acid derivatives in good isolated yields. Based on our mechanistic studies, a Pd(II)/Pd(IV) catalytic cycle that involves aroyl radical intermediate is proposed for the reaction.